この問題は難しすぎて、私にはお手上げだ。
This problem is too difficult; I'm at a loss.
部品が手に入らなければ、修理はお手上げです。
If we can't get the parts, there's nothing we can do about the repair.
相手にここまで値切られてはお手上げだよ。
When they haggle me down this far, I just have to throw up my hands.
停電でパソコンが使えず、みんなお手上げの状態だった。
With the power out and the computers down, everyone was completely stuck.