Senior Principal Scientist, Medicinal Chemistry

We’re looking to hire a Senior Principal Scientist of Medicinal Chemistry to join us in our mission to discover and develop drugs that improve human health through the use of breakthrough computational methods.

Our drug discovery and pre-clinical development team includes a cross-functional group of scientists and drug developers with experience working on all common target classes and therapeutic areas. We’re supported by more than 100 software developers and engineers, as well as a large-scale computational infrastructure to apply our proprietary physics-based drug design and optimization platform. Several programs we have worked on have achieved development candidates, including progression to clinical development and FDA approval. View our entire pipeline of wholly-owned programs and collaborations here.

Who will love this job

• A passionate scientist with a robust background in structure-based drug design
• A team player skilled at working in a dynamic, multidisciplinary environment
• An excellent communicator and presenter
• A dedicated collaborator who enjoys working with geographically distributed teams

What you’ll do

• Lead drug discovery programs in effective collaboration with global cross-functional teams, accounting for differences in time zone and work culture
• Execute medicinal chemistry strategies to deliver high-quality development candidates
• Collaborate effectively with computational chemists and modelers on the application of Schrödinger’s computational platform for rapid advancement of drug discovery programs
• Drive continuous improvement and implementation of new strategies for our Therapeutics Group’s experimental hit-finding capabilities
• Provide strategic and technical expertise to the Medicinal Chemistry team and the broader Therapeutics Group

What you should have

• PhD in synthetic organic or medicinal chemistry, or a related field
• At least ten years of drug discovery experience in a pharmaceutical and/or biotech setting
• Demonstrated track record in medicinal chemistry, as evidenced by successful advancement of drug discovery projects to clinical candidate nomination
• Excellent understanding of biology, pharmacology, drug metabolism and pharmacokinetics
• Demonstrated experience and expertise with modern experimental hit-finding techniques
• Extensive experience working with external chemistry teams at CROs
• Business-level proficiency in English and Japanese
• Hands-on experience advancing peptide modality programs is a plus

Pay and Perks:
Schrödinger understands that it’s people that make a company great. Because of this, we’re prepared to offer a competitive salary, bonus plan, and benefits, which includes mutual-aid retirement plans, over three weeks of paid vacation time, numerous company holidays, a parental leave program, and healthcare through our partnership with the Japanese Health Insurance Association, and professional development opportunities including trainings and continuous education support.